Category Archives: Amine preparation

Amine preparation

Primary aliphatic amines can be prepared by the reaction of ammonia with haloalkanes The mechanism is nucleophilic substitution R-Br + 2NH3 → R-NH2 + NH4+ Br− Otherwise, there is a tendency for the primary amine product to act as a nucleophile and react with the haloalkane, generating a secondary amine, R2NH. R-Br + R-NH2 → R2NH + HBr Furthermore, the secondary amine will react

Read more