Category Archives: 3.11 Amines

Nucleophilic properties of amines

Amines are nucleophiles The nucleophilic substitution reactions (including mechanisms) of ammonia and amines with haloalkanes to form primary, secondary, tertiary amines and quaternary ammonium salts. The use of quaternary ammonium salts as cationic surfactants. The nucleophilic addition–elimination reactions of ammonia and primary amines with acyl chlorides and acid anhydrides [in new syllabus from 2015]. Students should be able to outline the mechanisms of: • these nucleophilic

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Amine preparation

Primary aliphatic amines can be prepared by the reaction of ammonia with haloalkanes The mechanism is nucleophilic substitution R-Br + 2NH3 → R-NH2 + NH4+ Br− Otherwise, there is a tendency for the primary amine product to act as a nucleophile and react with the haloalkane, generating a secondary amine, R2NH. R-Br + R-NH2 → R2NH + HBr Furthermore, the secondary amine will react

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